We try to keep things flexible. So for MLB, NBA, and NHL Friends Mode leagues, you can select which day(s) you want your contest(s) to run each week. You can expect the contest to be available for entry at about 8 PM the day prior to game start.
EPL leagues run on Saturdays..
PGA leagues run on Thursdays.
NFL leagues run on Sundays Only or Sunday-Monday.
For these three sports, the contests become available for entry on Tuesdays at about noon ET. So be sure to get any edits to your contest size or settings in before then.
NOTE: Keep in mind these are subject to change.